منابع مشابه
Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders.
BACKGROUND Mutations in the glucocerebrosidase (GBA) gene have been reported to modify risk for Parkinson disease (PD) and dementia with Lewy bodies (DLB). However, these findings have not been consistently replicated, and most studies have had substantial methodological shortcomings. OBJECTIVE To better assess the role of GBA variants in altering risk for Lewy body disorders. DESIGN Case-c...
متن کاملImpairment of script comprehension in Lewy body spectrum disorders.
A disabling impairment of higher-order language function can be seen in patients with Lewy body spectrum disorders such as Parkinson's disease (PD), Parkinson's disease dementia (PDD), and dementia with Lewy bodies (DLB). We focus on script comprehension in patients with Lewy body spectrum disorders. While scripts unfold sequentially, constituent events are thought to contain an internal organi...
متن کاملDecision-Making Deficits Associated with Amyloidosis in Lewy Body Disorders
Background: Lewy body disorders (LBD) are clinical syndromes characterized by pathological inclusions containing α-synuclein. Cognitive deficits are common or diagnostic in LBD, and may be associated with the presence of beta-amyloid (Aβ), which is a hallmark histopathologic abnormality characteristic of Alzheimer's disease (AD) that can also co-occur with LBD. Objective: In the present study w...
متن کاملCholinesterase Inhibitors for Lewy Body Disorders: A Meta-Analysis
BACKGROUND We performed a meta-analysis of cholinesterase inhibitors for patients with Lewy body disorders, such as Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies. METHODS The meta-analysis included only randomized controlled trials of cholinesterase inhibitors for Lewy body disorders. RESULTS Seventeen studies (n = 1798) were assessed. Cholinesterase inhib...
متن کاملBiomarkers in Alzheimer's Disease and Lewy Body Disorders with Dementia
1 Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Calwer Str. 14, 72076 Tuebingen, Germany Alzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 86 Stockholm, Sweden German Center for Neurodegenerative Diseases (DZNE), Otfried Müller-Strasse 27, 72076 Tuebingen, Germany 4 Section for Dementia Research, Hert...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurologic Clinics
سال: 2017
ISSN: 0733-8619
DOI: 10.1016/j.ncl.2017.01.004